Our management team has decades of experience leading successful initiatives in pharmaceutical discovery, development, and commercialization.

Daniel M. Schmitt,    President & CEO

Mr. Schmitt brings 30 years of successful industry experience in operations management, new product development, and business development, having held senior executive positions in both large pharmaceutical and small biotechnology companies, including Fujisawa, Searle / Pharmacia, and Ilex Oncology. During his career, Daniel has led and contributed to the successful development and launch of over 12 pharmaceutical products, and has constructed and executed numerous high value licensing, acquisition, and development deals for biotech and pharmaceutical companies totaling nearly $1 billion in upfront and potential milestone payments.

Mr. Schmitt received his M.B.A and a B.S. in Chemistry and Theoretical Mathematics from West Virginia University, and has held research positions affiliated with the National Foundation for Cancer Research and at the University of North Carolina School of Medicine. He serves as an Entrepreneur-in-Residence at Northwestern University, and as an external expert consultant for the University of Chicago and the University of Illinois-Chicago. Mr. Schmitt is also a founding member of Chicago Innovation Mentors.

Francis J. Giles, MB, MD, FRCPI, FRCPath     Chief Medical Officer

As Chief Medical Officer, Dr. Giles is responsible for advancing Actuate’s research and development initiatives, leading the clinical programs, and supporting external collaborations and strategic partnerships. In addition to his role as CMO for Actuate, Dr. Giles currently serves as Director of Developmental Therapeutics at the Robert H. Lurie Comprehensive Center of Northwestern University where he has also served as Deputy Director and as Chief of the Division of Hematology/Oncology, Northwestern University Feinberg School of Medicine. He previously served as Deputy Director of the Cancer Therapy and Research Center at the University of Texas (UT) Health Science Center, San Antonio, and Chief of the Division of Hematology and Medical Oncology and Director of the Institute for Drug Development. His prior positions include serving as Chairman, Clinical Research Committee, and Professor in the Division of Cancer Medicine at the UT MD Anderson Cancer Center, Houston; and as a faculty member at the University of California, Los Angeles, and the University of North Carolina at Chapel Hill. He is the founder and Chairman of both the International Oncology Study Group and the Developmental Therapeutics Consortium. Dr. Giles has led the development of novel drugs, immunotherapies, and other highly targeted approaches, including cancer-directed viruses, monoclonal antibodies, and molecularly directed agents. He has served as principal investigator on numerous national and international First in Human, Phase I, II, and III clinical studies of many novel agents, and holds numerous patents and technology licenses.

Andrew P. Mazar, Ph.D.    Scientific Co-Founder

Dr. Mazar serves as the Entrepreneur-in-Residence and the Director, Center for Developmental Therapeutics (CDT) within the Chemistry of Life Processes Institute at Northwestern University.  Prior to joining Northwestern University, Dr. Mazar was the Chief Scientific Officer at Attenuon, LLC in San Diego and led discovery and development efforts resulting in three drugs entering oncology clinical trials.

Dr. Mazar is the Chair of the NCI Nano Alliance Animal Model working group and a member of the NHLBI Scientific Review Board (SRB) for the SMARTT program, serves as Associate Editor for Recent Patent Reviews on Anti – Cancer Drug Discovery and is a member of the editorial board of Clinical Cancer Research.  He is also the co-author of 99 peer reviewed publications and 16 reviews and book chapters.  Dr. Mazar has founded or advised several start-up companies over the past 5 years and has been involved in raising >$120M in investment and partnership capital for these entities. 

Andrey Ugolkov (Ougolkov), M.D., Ph.D.     Scientific Advisor

Dr. Ugolkov is a Research Assistant Professor in the Center for Developmental Therapeutics, Robert H. Lurie Comprehensive Cancer Center at Northwestern University and is a recognized expert on GSK-3 research in oncology.  Through his research, Dr. Ugolkov identified GSK-3 as a viable new therapeutic target in human cancer. Dr. Ugolkov brings extensive experience in clinical oncology, pathology and cancer research including establishment of heterotopic, orthotopic and metastatic xenograft tumor models. He is widely published in peer reviewed journals on the identification of new therapeutic targets in human cancer, and in pre-clinical testing of new anticancer drugs including GSK-3 inhibitors.

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