Our focus is on the development of compounds for combination use in high impact carcinomas including glioblastoma, ovarian, breast, and pancreatic cancers. We have completed studies of our lead compound, 9-ING-41, in preclinical patient-derived xenograft models of cancers, including both drug sensitive and drug resistant glioblastoma, results of which are quite compelling, including complete and durable regressions of disease without recurrences, and significant increases in overall survival. Our compounds have been well tolerated and have demonstrated a favorable pharmacokinetic profile.
In addition, we are advancing research for the development of our compounds for the treatment of inflammation leading to fibrosis and neurodegeneration, where results of early studies in animal models are promising.
The Company has completed pharmacology and toxicology studies and our lead drug candidate demonstrated very favorable pharmacokinetic and tox profiles. A groundbreaking Phase 1/2 trial across multiple histologies is ready to be initiated in leading institutions worldwide.