Molecular pathways: revisiting glycogen synthase kinase-3β as a target for the treatment of cancer
Clinical Cancer Research, 2017; DOI: 10.1158/1078-0432.CCR-15-2240; Amy Walz, Andrey Ugolkov, Sunandana Chandra, Alan Kozikowski, Benedito A. Carneiro, Thomas V. ,O’Halloran, Francis J. Giles, Daniel D. Billadeau, and Andrew P. Mazar

Targeting GSK-3: a promising approach for cancer therapy?
Future Oncology, 2006; 2(1):91-100; Ougolkov A, Billadeau DD.

Combination treatment with the GSK-3 inhibitor 9-ING-41 and CCNU cures orthotopic chemoresistant glioblastoma in patient-derived xenograft models
Translational Oncology; 2017 Aug; 10(4):669-678; Andrey Ugolkov, Wenan Qiang, Gennadiy Bondarenko, Daniel Procissi, Irina Gaisina, C. David James, James Chandler, Alan Kozikowski, HendraGunosewoyo, Thomas O’Halloran, Jeffry Raizer and Andrew P. Mazar

Potential therapeutic effect of glycogen synthase kinase 3β inhibition against human glioblastoma.
Clin Cancer Res 2009; 15:887-897; Miyashita K, Kawakami K, Nakada M, Mai W, Shakoori A, Fujisawa H, Hayashi Y, Hamada J, Minamoto T.

GSK3β regulates differentiation and growth arrest in glioblastoma
PLoS One 2009;4(10):e7443; Korur S, Huber RM, Sivasankaran B, Petrich M, Morin P Jr, Hemmings BA, Merlo A, Lino MM.

Glycogen synthase kinase-3 inhibition induces glioma cell death through c-MYC, nuclear factor-κB, and glucose regulation.
Cancer Res 2008; 68(16):6643-6651; Kotliarova S, Pastorino S, Kovell LC, Kotliarov Y, Song H, Zhang W, Bailey R, Maric D, Zenklusen JC, Lee J, Fine HA.

Glycogen synthase kinase-3 inhibition sensitizes pancreatic cancer cells to chemotherapy by abrogating the TopBP1/ATR-mediated DNA damage response
Clinical Cancer Research; September 18 2019 DOI:10.1158/1078-0432.CCR-19-0799; Li Ding, Vijay S. Madamsetty, Spencer Kiers, Olga Alekhina, Andrey Ugolkov, John Dube, Yu Zhang, Jin-San Zhang, Enfeng Wang, Shamit K. Dutta, Daniel M. Schmitt, Francis J. Giles, Alan P. Kozikowski, Andrew P. Mazar, Debabrata Mukhopadhyay, and Daniel D. Billadeau

Glycogen synthase kinase-3β ablation limits pancreatitis-induced acinar-to-ductal metaplasia
Journal of Pathology; 2017 Sep; 243(1):65-77; Li Ding, Geou-Yarh Liou, Daniel M Schmitt, Peter Storz, Jin-San Zhang and Daniel D Billadeau

Glycogen synthase kinase-3β participates in nuclear factor kappaB-mediated gene transcription and cell survival in pancreatic cancer cells.
Cancer Res, 2005; 65:2076-2081; Ougolkov A, Fernandez-Zapico M, Savoy D, Urrutia R, Billadeau D.

From a natural product lead to the identification of potent and selective benzofuran-3-yl-(indol-3-yl)maleimides as glycogen synthase kinase 3β inhibitors that suppress proliferation and survival of pancreatic cancer cells.
J Med Chem 2009; 52:1853-1863; Gaisina I, Gallier F, Ougolkov A, Kim K, Kurome T, Guo S, Holzle D, Luchini D, Blond S, Billadeau D, Kozikowski A.

Aberrant nuclear accumulation of glycogen synthase kinase-3β in human pancreatic cancer: association with kinase activity and tumor dedifferentiation.
Clin Cancer Res 2006; 12:5074-5081; Ougolkov A, Fernandez-Zapico M, Bilim V, Smyrk T, Chari S, Billadeau D.

GSK-3 inhibition overcomes chemoresistance in human breast cancer
Cancer Letters, 2016; 380:384–392; Andrey Ugolkov, Irina Gaisina, Jin-San Zhang, Daniel D. Billadeau, Kevin White, Alan Kozikowski, Sarika Jain, Massimo Cristofanilli, Francis Giles, Thomas O’Halloran, Vincent L. Cryns, Andrew P. Mazar

Glycogen synthase kinase-3β positively regulates protein synthesis and cell proliferation through the regulation of translation initiation factor 4E-binding protein 1.
Oncogene 2014; 33:1690-99; Shin S, Wolgamott L, Tcherkezian J, Vallabhapurapu S, Yu Y, Roux PP, et al.

Glycogen synthase kinase 3β inhibitors induce apoptosis in ovarian cancer cells and inhibit in-vivo tumor growth.
Anticancer Drugs 2011; 22:978-985; Hilliard T, Gaisina I, Muehlbauer A, Gaisin A, Gallier F, Burdette J.